Adjunctive Minocycline for Negative Symptoms In a placebo-controlled trial, the addition of minocycline to risperidone improved negative symptoms in early-stage schizophrenia. Background: Minocycline is a second-generation tetracycline with apparent neuroprotective
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چکیده
Background: Minocycline is a second-generation tetracycline with apparent neuroprotective effects. It reportedly blocks the activation of microglia, preventing the release of cytokines that are believed to contribute to schizophrenia. Minocycline also helps to maintain normal glutamatergic neurotransmission. Although the exact mechanism is unknown, results of animal studies and several human trials suggest minocycline may be useful against negative symptoms of schizophrenia.
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A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia.
BACKGROUND Current antipsychotics have only a limited effect on 2 core aspects of schizophrenia: negative symptoms and cognitive deficits. Minocycline is a second-generation tetracycline that has a beneficial effect in various neurologic disorders. Recent findings in animal models and human case reports suggest its potential for the treatment of schizophrenia. These findings may be linked to th...
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